Heterogeneous tau deposition patterns in the preclinical stage link to domain-specific cognitive deficits.

Conversely, in the case of IC7 with bilateral entorhinal cortex involvement, the IC expression demonstrated a highly significant association only with age ( t = 4.05, p < 0.00006) and the association with Aβ attenuates substantially to a statistically insignificant level.

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In the visual retention domain, the Benton visual retention test match score analysis revealed a marginally significant negative association with IC3 tau uptake, with a bilateral temporal‐occipital pattern ( t = −2.01, p < 0.047), suggesting a potential link between tau accumulation in this IC map and visuospatial capabilities.

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