Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy.

Ferroptosis Pathway Interestingly, KEGG pathway enrichment analysis demonstrated that ferroptosis (ID: hsa04216) ( Figure 4 A) was enriched at a highly significant level ( p -value = 6.79 × 10 −8 versus control) for the dual treatment (PRO plus CAP) than in other single treatments ( p -value = 0.05; PRO, p -value = 3.34 × 10 −6 for CAP versus control), which confirmed the synergistic interaction of the dual treatment that was obtained from the cytotoxicity study.

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