highly significantp < 0.0001
Using DBS, the upstream control element (UCE) and core promoter (CP) region as well as the 5′ external transcribed spacer (ETS) showed highly significant correlations between methylation and age (UCE/CP ρ = 0.68; p < 0.0001 and ETS ρ = 0.60, p < 0.0001) ( Figure S1B ).