GLIO-Select: Machine Learning-Based Feature Selection and Weighting of Tissue and Serum Proteomic and Metabolomic Data Uncovers Sex Differences in Glioblastoma.

Overall, both purine metabolism and fatty acid metabolism have been reported as highly significant in GBM, with emerging relationships to tumor resistance [ 53 , 54 , 55 ], and the current analysis supports that, indeed, several compounds may be captured in the serum and tumor tissue of patients with GBM, leading to potential mechanistic relationships for further research.

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