Geographical characteristics and formation mechanisms of smallpox epidemics in Hubei Province, China, 1488-1949.

The results showed that the UF value was less than 0 during the period from 1912–1931, indicating that smallpox in the Republic of China had a decreasing trend during the period from 1912–1931, and the UF value exceeded the 0.05 significance threshold during the period from 1920–1924, which indicated that the decreasing trend in this period was very significant; during the period from 1931–1944, it was very significant.

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The smallpox epidemic in Hubei Province showed an overall trend of “light at the beginning and heavy at the end” in terms of time changes, mainly concentrated in the Republic of China period, especially in the 1940s.

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