Analysis and comparison of the trends in burden of malignant cutaneous melanoma in East Asian countries and regions and worldwide from 1991 to 2021.

However, the global APC of ASIR and ASPR had an increasing trend from 1991–2009 and a decreasing trend from 2009–2021.

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The ASDR of China, South Korea, and Global MM showed an overall decreasing trend from 1991–2021, North Korea was a slightly increasing trend, while Japan and Taiwan province were more fluctuating ( Figure 5 ).

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Let us take China as an example, the annual rate of change (APC) of ASIR is in an increasing trend from 1991–2021, and there is a rapidly increasing trend after 2004 that lasts until 2012 (1991–1994 APC = 2.41; 1994–2004 APC = 0.44; 2004–2012 APC = 4.44; 2012–2016 APC = 1.65; 2016–2019 APC = 2.61; 2019–2021 APC = 1.54; p < 0.05).

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