Barely Significant
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Effect of methotrexate/dexamethasone combination on epithelial-mesenchymal transition and inflammation gene expression of human RPE cells <i>in-vitro</i>.

Front Pharmacol · 2025 · PMC12075955 · PMID 40371355

Europe PMCDOI
1
hedged sentence
0.0630
closest p · 1.3× alpha
0.0630
boldest claim

The sentences

marginally significantp-value = 0.063so close (0.05 < p ≤ 0.1)
The mRNA expression of anti-apoptotic BCL-2 showed a marginally significant downregulation at the concentration of 100 μg/mL MTX compared to 400 μg/mL concentration (0.38 ± 0.11, p-value = 0.063); moreover, the BCL-2/BAX ratio -at x concentration of MTX-was significantly lower than 1:1 (0.33 ± 0.12, P-value = 0.019), implying the pro-apoptotic effect of this dose on RPE cells ( Figure 3B ).

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