Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A_2A receptor.

Notably, intraperitoneal administration of ARC resulted in an increasing trend (albeit statistically non-significant) in lean mass in mice.

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We also observed the levels of TG, TC, HDL, LDL, and FFA in serum, which showed a decreasing trend in mice treated with ARC (Fig. 1 N-R).

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