The dual roles of human PYHIN family proteins in cancer: mechanisms and therapeutic implications.

Front Immunol · 2025 · PMC12081459 · PMID 40386782

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IFI16 in colorectal cancer The phenotypic expression characterized by IFI16 negativity combined with Ki-67 positivity (IFI16-/Ki-67+) has been notably and positively correlated with advanced TNM staging in cancer patients, and it exhibits a borderline significant link to lymph node metastasis, as reported in a pivotal study ( Table 2 ) ( 128 , 129 ).

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