Specifically, these results could be related to decreased amplitude of wave IV (an area that may represent MNTB processing) of the ABR in female Fmr1 KO mice (compared to female Fmr1 KO heterozygotes—almost significant compared to wild-type), however, further work directly linking mitochondrial issues to ABR phenotypes would need to be performed to validate this connection.
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Sex-specific loss of mitochondrial membrane integrity in the auditory brainstem of a mouse model of Fragile X Syndrome.
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