Assessment of baseline samples revealed an overall trend of enrichment in pathways dedicated to innate and adaptive immune system activation, T cell signaling, and antigen presentation in the CD33 + myeloid cells of responders in contrast to enrichment of dysregulated signaling in those of non-responders (Fig. 4 a).
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Responses to checkpoint inhibition in metastatic triple negative breast cancer driven by divergent myeloid phenotypes.
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