OGG1S326C variant frequent in human populations facilitates inflammatory responses due to its extended interaction with DNA substrate.

Proc Natl Acad Sci U S A · 2025 · PMC12088383 · PMID 40343995

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highly significantno p-value reported

The results showed that while WT -OGG1 poorly underwent intermolecular interaction upon TNFα exposure, interaction between OGG1S326C molecules was highly significant.

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