TODO: A Triple-Outcome Double-Criterion Optimal Design for Dose Monitoring-and-Optimization in Multi-Dose Randomized Trials.

Stat Med · 2025 · PMC12089520 · PMID 40390185

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a decreasing trendno p-value reported

Scenarios 1.8 and 1.9 exhibit a decreasing trend in efficacy with the increasing dose, thereby favoring the lower dose d 1 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.