CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition.

Only a small number of patients were identified to carry CREBBP mutations, therefore to more holistically link CREBBP-activity to ferroptotic susceptibility, we correlated gene sets involved in ferroptosis with CREBBP expression, demonstrating a highly significant negative correlation ( R = –0.42, p = 6.6e –10 ) (Supplementary Data Table 4 , Fig. 5f ).

also in 132,142 other papers