Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes.

36 , 37 , 49 , 50 , 51 , 52 Downstream repercussions of changes in tail‐anchored protein insertion in neurons are likely to be significant: mutations in the GET protein WRB, for example, result in neuronal phenotypes. 53 , 54 Thus, future validation studies investigating the consequences of changes in CAMLG expression, and of V78I, on neuronal lysosomal function and handling of “proteinopathies” such as misfolded aSyn in model systems such as neuronal culture or transgenic animals, are easy to envision and would be a valuable addition to the work presented here.

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