Longitudinal impact of different treatment sequences of second-generation antipsychotics on metabolic outcomes: a study using targeted maximum likelihood estimation.

For FG, the highest ATE was observed at 6 months, followed by a decreasing trend.

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The trends before 6 months are not captured in Figure 2 but can be observed in Supplementary Figure S1 . Notably, for FG, the ATEs peaked at 4 months and then gradually decreased until 12 months, with a slightly increasing trend between 12 and 18 months (Supplementary Figure S1 ).

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Main findings In general, the ATEs for BMI and TG showed an increasing trend from 6 to 12 months, followed by a decline from 12 to 18 months.

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