High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice.

Here, we sorted all genes expressed in the liver ( N = 13.426) based on gene length and clustered them in bins of 500, revealing that increased dietary protein intake triggers GLTD as indicated by a statistically highly significant downregulation of longer genes in LCHP vs LPHC diets (Fig. 3H , p = 1.89E-12).

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