Impact of Condoliase on Health-related Quality of Life in Participants With Radicular Leg Pain Associated With Lumbar Disk Herniation: Results From a United States Phase 3 Clinical Trial.

Spine (Phila Pa 1976) · 2025 · PMC12101895 · PMID 40066868

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did not achieve significanceno p-value reported

placebo) did not achieve significance in the Japanese phase 2/3 trial, 14 the Japanese phase 3 trial found that condoliase treatment resulted in significantly greater improvements in SF-36 PCS versus placebo at weeks 13 and 52. 17 Consistent with the Japanese phase 3 study, 17 the impact of condoliase on the mental component of the SF-36 (ie, MCS) was minimal.

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