Notably, in 432 adolescents (11 – 17 years old) a marginally significant negative linear association and a significant curvilinear relationship were found between hair cortisol and depressive symptoms [ 60 ].
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Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial.
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