The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implications.

132 This difference may be significant for using saliva as a proxy for the brain—the causal tissue for behavior—in epigenetic research because both buccal epithelial cells and neurons are derived from the ectodermal layer during development. 133 Furthermore, blood OXTR methylation levels may reflect systemic, trait levels that can account for individual differences in established brain network patterns whereas other tissue types may provide a more plastic and dynamic understanding of OXTR m variability over time.

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