156 , 157 A RCT with safinamide did not found significant differences between treated and untreated groups, but post-hoc analyses revealed a positive trend, warranting further investigation in larger studies. 158 Other studies with SNRIs (duloxetine) and SSRIs (paroxetine and escitalopram) have not demonstrated significant effects on apathy, despite the known emotional component present in some patients. 159 Non-pharmacological interventions Non-pharmacological therapies for apathy in PD offer promising but very limited evidence.
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Approaches for treating neuropsychiatric symptoms in Parkinson's disease: a narrative review.
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