Beyond <i>Trypanosoma cruzi</i>: LINE-1 Activation as a Driver of Chronic Inflammation in Chagas Disease.

A statistical analysis confirmed a highly significant difference between infected and control groups at these time points ( p < 0.0001; Figure 1 A), with a 37.6-fold increase at 48 hpi and a 136.7-fold increase at 96 hpi.

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Regarding type I IFNs, IFN-α exhibited a decreasing trend in the transfected and infected group compared to the infected group ( p = 0.06), while IFN-β expression was significantly downregulated in the transfected group ( p = 0.05; Figure 2 E and Figure 2 F, respectively).

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