Icariin Ameliorates Cyclophosphamide-Induced Renal Encephalopathy by Modulating the NF-κB and Keap1-Nrf2 Signaling Pathways.

The increase was more evident in the 100 mg/kg ICA group compared with the 25 mg/kg ICA group, with a highly significant difference (*** p < 0.001).

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In Vivo Results Changes in the body weight of mice ( Figure 2 A) showed that compared with the control group, the CTX group had already shown a decreasing trend in body weight at about day 13, and with the lengthening of the administration time of CTX and ICA, the comparison of the combination of the preliminary observations revealed that the weight loss of mice in the CTX group was accelerated.

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