Endophenotype-Informed Association Analyses for Liver Fat Accumulation and Metabolic Dysfunction in the Fels Longitudinal Study.

To determine statistical significance, we used a two-tier thresholding strategy: a genome-wide marginal significance threshold of p ≤ 1.0 × 10 −4 (uncorrected), and a Bonferroni-corrected significance threshold computed based on the number of SNPs analyzed within each linkage-defined region.

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Targeted association analyses within the -1-LOD score regions of these QTLs revealed 17 marginally significant single nucleotide polymorphisms (SNPs) associated with liver fat content or its combination with the selected endophenotypes.

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