Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth.

Upon treatment with 25 mg/kg of compound 12 , there was an increasing trend in the infiltration of total immune cells (CD45 + cells) ( Figure 4 C), and the tumor infiltration of total TAMs, TAMs with the M2-liketumor-promoting phenotype (CD206 + TAMs), and immunosuppression TAMs (ARG1 + TAMs) in CD45 + cells was significantly reduced ( Figure 4 D–F), accompanied by the marginal upregulation of TAMs with the M1-like phenotype (CD86 + TAMs, MHC II + TAMs) ( Figure S3A,B ).

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