3D genome organization shapes DNA damage susceptibility to platinum-based drugs.

Nucleic Acids Res · 2025 · PMC12117463 · PMID 40433977

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[ 60 ] compared gene expression in cisplatin-treated cells to untreated control and found a modest but highly significant negative correlation ( P = −0.36, P -value: < 2.2e-16) between gene expression fold change and the number of cisplatin-induced damage sites within a gene.

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