Insulin resistance reduction, intermittent fasting, and human growth hormone: secondary analysis of a randomized trial.

In the present 26-week study of a once-per-week 24-hour fasting regimen, exploratory analyses revealed an increase in HGH concentrations for subjects with initially low baseline HOMA-IR (≤2.20) but no difference in HGH change for those with higher baseline HOMA-IR (>2.20), with a weak trend for the presence of effect modification ( p = 0.07).

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Tests of effect modification were highly significant for an interaction of lower HGH and fasting in triggering substantial changes of HOMA-IR, insulin, and glucose.

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