Risk and prognosis of second primary malignancies in patients with follicular lymphoma in the era of rituximab: A population study based on the SEER database.

To address confounding, we implemented a rigorous covariate selection protocol: first, clinically plausible variables were pre-specified through literature review; second, univariate screening with an inclusive threshold (P ≤ 0.2) retained marginally significant factors; finally, multivariable models incorporated these predictors alongside established prognostic variables.

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