BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.

Nat Commun · 2025 · PMC12119881 · PMID 40436896

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highly significantno p-value reported

Nolatrexed treatment resulted in a highly significant decrease in both IdU track length and fork speed by ~50%, indicating that it was causing replication stress (Supplementary Fig.

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