highly significantp -value < 0.001
Furthermore, compound 24 caused highly significant ( p -value < 0.001) down-regulation of the gene expressions of ORF1a / b , ACE-2 , and RdRp with fold-changes of 2.05, 0.58, and 1.4, respectively (Fig. 4 A–E) as compared to the drug control RDV.