Clinical and molecular implications of cGAS/STING signaling in checkpoint inhibitor immunotherapy.

Front Mol Biosci · 2025 · PMC12122296 · PMID 40452917

Europe PMC DOI

hedged sentence

0.0830

closest p · 1.7× alpha

0.0830

boldest claim

The sentences

marginal significanceP = 0.083so close (0.05 < p ≤ 0.1)

Furthermore, we adopted the model to explore the association of STING signaling with immunotherapy benefit and found that an improved immune response in the Mariathasan2018_PD-L1, Kim2018_PD-1, Gide2019_combined, Jung2019_PD-1/L1, and Gide2019_PD-1 datasets (logistic regression model, P < 0.05) and marginal significance in Riaz2017_progPD-1 ( P = 0.083) ( Figure 1A ).

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