Comparative analysis of trends in the burden of motor neuron disease in China, the United States, and globally from 1990 to 2021: projections for 2022-2041.

In terms of mortality, the peak mortality for MND in both 1990 and 2021 occurred in the 70–74 age group, with the CMR showing an increasing trend in the 5–79 age group and a decreasing trend after 80 years of age ( Supplementary Figure 1C ).

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The crude incidence rate (CIR) showed a declining trend in the 0–14 age group, but an increasing trend in the 20–69 age groups ( Figure 4A ).

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