Endogenous Retroelement Activation is Implicated in Interferon-α Production and Anti-Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis.

There was no significant association between the whole‐blood IGS and LINE‐1 transcription expression (Figure 1D ), despite a positive trend ( P = 0.06) between the IGS and circulating IFN‐α (data not shown).

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There was a trend toward increased expression of ERE in patients with eRA in all subsets, which became highly significant for naïve B cells (Figure 3B ).

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