Incidence, Risk and Trends of Multiple Primary Cancers in Patients With Colorectal Cancer: Evidence From the South Australian Cancer Registry.

Cancer Med · 2025 · PMC12123453 · PMID 40444502

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an increasing trendno p-value reported

The findings revealed a significantly higher risk of subsequent primary cancers, with an increasing trend over time.

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marginally significantno p-value reported

When limited to extracolonic sites, the risk of non‐CRC MPC was still elevated compared to the corresponding risk of cancer in the general population with a SIR of 1.11 (95% CI: 1.08, 1.15; AER = 18.8, 95% CI: 16.9, 20.9); however, this significant elevation in risk was primarily in males (SIR = 1.10, 95% CI: 1.06, 1.15; AER = 21.4, 95% CI: 18.5, 24.5), while it was marginally significant in females (SIR = 1.05, 95% CI: 1.00, 1.10).

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