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Identifying genes and traits associated with pre-eclampsia using summary statistics.

PLoS One · 2025 · PMC12124566 · PMID 40445995

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an increasing trendno p-value reported
The initial rise in urinary ANG-(1–7) was detected at 12 weeks of gestation, but an increasing trend was observed as early as week 6 of pregnancy, suggesting that early adaptive changes in the renal RAS system may contribute to changes in fluid and electrolyte balance throughout pregnancy.

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