Chlorogenic acid attenuates oxidative damage in rat lacrimal gland epithelial cells via PI3K/AKT/FoxO3 signaling: network pharmacology and experimental evidence.

Sci Rep · 2025 · PMC12125342 · PMID 40447676

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a decreasing trendno p-value reported

However, while total Caspase3 levels significantly increased in the H2O2 model group and the MK-2206 + CGA group ( P < 0.05), cleaved-Caspase3 levels showed a decreasing trend (Fig. 7 B and D).

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an increasing trendno p-value reported

On the other hand, compared to the CGA-treated group, there was an increasing trend in the apoptosis signal in the CGA and MK-2206 co-treated group, and a decreasing trend in the CGA and SC79 co-treated group, but neither reached statistical significance ( P > 0.05).

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