CpG dinucleotide methylation of the SPDEF gene as a blood-based epigenetic biomarker for prostate cancer diagnosis.

To further validate these findings, linear regression analysis confirmed a strong positive correlation between SPDEF hypomethylation and both tumor stage ( r = 0.9574) and ISUP grade ( r = 0.9348), with narrow confidence intervals and highly significant P values (< 0.0001; Fig. 2 C and D).

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