Neovascular pruning by IDO1 inhibitors can potentiate immunogenic cytotoxicity of ischemia-targeted agents to synergistically enhance anti-PD-1 responsiveness.

In contrast, combining epacadostat+evofosfamide at the 150 mg/kg evofosfamide dose with anti-PD-1 markedly increased median survival relative to untreated mice by nearly 2.5 weeks with a highly significant p value of 0.0026 and an HR of 0.25 ( figure 7B ).

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