Impact of Angiotensin Receptor-Neprilysin Inhibitor Therapy on Cardiac Remodeling in Patients with Heart Failure and Reduced Ejection Fraction.

Compared with traditional RAAS inhibitors, ARNIs induced more LVRR in terms of LVEF improvement and volume reduction.[ 2 ] In our study, significant improvement was observed in the ACEI group in volumetric parameters, systolic function (LVEF), indexed LV mass, and diastolic function assessed by LAVI and E/e’, yet no improvement was detected in the deformation parameters assessed by both 2D GLS and 3D GLS compared to the highly significant improvement seen in treatment with ARNI.

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