Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma.

Cancer Discov · 2025 · PMC12130810 · PMID 39704522

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an increasing trendno p-value reported

Whereas multiple cell types can produce various chemokines and cytokines (e.g., CXCL9 , CCL3 , and TNF ), the data showed an increasing trend of gene expression associated with both M1 and M2 macrophages ( 84 ) in the cancer group, including stabilin-1 ( STAB1 ), AXL , IL10 , and CD163 (Supplementary Fig.

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