Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods.

In our study, the population showed a decreasing trend in F/B ratio after a short-term acute entry into the highland, which might lead to a weakened energy intake and utilization capacity and short-time weight loss during the initial period after entering the highland.

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The relative abundance of Bacteroidetes showed an increasing trend in G-I, G-II, and G-III, while the relative abundance of Proteobacteria and Actinobacteria showed a downward trend, especially in G-III ( Fig. 4A ).

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