HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large cell lymphoma: implications for HDAC inhibitor therapy.

Leukemia · 2025 · PMC12133565 · PMID 40175628

Europe PMC DOI

hedged sentence

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

borderline significancep = 0.059so close (0.05 < p ≤ 0.1)

Hdac1 KO samples showed a smaller reduction in overall HDAC activity (average reduction of 12,4%) with borderline significance compared to NPM::ALK tumors ( p = 0.059), reflecting the compensatory function of HDAC2.

also in 7,017 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.