Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.

Consistently, Western blotting results suggested that the protein levels of HIF-1α, BNIP3, and NIX were significantly increased or showed an increasing trend after hypoxia treatment ( Figures 2H–O ). 3.5 Hypoxia treatment reduces cell viability and angiogenic capability Renal tubules generally have a regenerative ability that contributes to functional recovery after renal injury, which is closely related to the migration, proliferation, and reconstruction of physiological functions of renal tubular cells ( 34 ).

also in 63,971 other papers