Barely Significant
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Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies.

J Crohns Colitis · 2025 · PMC12134891 · PMID 40464295

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of borderline significanceno p-value reported
Immunomodulatory molecule loci-smoking interaction Interaction of IL1B (rs1143627) and former smoking on UC risk was of borderline significance ( P interaction =.05). 39 The increased UC risk for former smoking was only seen in those with CT/CC genotype compared with never smokers with TT genotype. 39 No interaction was seen for CD. 39 In addition, 4 polymorphisms in IL10 (rs1800872, rs1800871, 1800896, and rs3024505) did not demonstrate s

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