Global Epidemiology of Early-Onset Digestive System Malignancy: A Systematic Analysis for the Global Burden of Disease Study 2021.

J Gastroenterol Hepatol · 2025 · PMC12136802 · PMID 40401498

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an increasing trendno p-value reported

Although most cancers predominantly occur in individuals over 50 years, there is an increasing trend in early‐onset cancers (< 50 years), which was also termed the “early‐onset cancer epidemic” [ 3 ].

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a decreasing trendno p-value reported

Overall, the ASMR and ASDR of early‐onset digestive system malignancies showed a decreasing trend globally from 2022 to 2030 (Figure 4B,C ). 4.

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