Barely Significant
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The Benefits of Estradiol on Cognitive Aging in Rats Are Independent From Its Effects on Cardiometabolic Health.

Endocrinology · 2025 · PMC12138191 · PMID 40420824

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a nonsignificant trendno p-value reported
However, a nonsignificant trend was observed, suggesting women who initiated hormone therapy closer to menopause might have a reduced risk compared with those more distant from menopause.

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