Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women.

J Ovarian Res · 2025 · PMC12139174 · PMID 40468347

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0.0010

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantp < 0.001actually significant

Furthermore, the pro-inflammatory marker S100A8 showed a substantial and highly significant difference between PCOS-Ln and PCOS-OW groups ( p < 0.001), highlighting its critical involvement in the obesity-related pathophysiology of PCOS (Fig. 6 E).

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an increasing trendp > 0.05actually significant

Furthermore, Pearson correlation analysis demonstrated a significant positive correlation between sEV protein concentration and BMI within the PCOS group ( p = 0.006), whereas the control group exhibited an increasing trend without statistical significance ( p > 0.05, Fig. 1 E).

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