KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition.

Cell Rep · 2025 · PMC12140508 · PMID 39908143

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highly significantno p-value reported

Furthermore, the KMT2C/D dKO and KMT2C/D dCD cells showed a highly significant reduction in origin firing, as seen by reduced asymmetry, in the most highly impacted RT bins (quartiles 1 and 2, red and purple lines).

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