Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions.

Therefore, we plotted the correlation coefficients (ρ) of PBR and capillary density with each of the 72 differentially regulated parameters (and another 53 with a statistical trend) between patients and healthy volunteers ( Figures 5E, F ).

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They also observed an overall trend toward decreased HLA-DR expression on CD14+ monocytes in sepsis, which is an accepted surrogate marker of sepsis-induced immunosuppression ( 22 ).

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