Model systems and unique biological features of high and low-grade colorectal cancer (CRC) revealed by xenografting 84 human CRC cell lines.

Correlation of the magnitude of differential expression of the differentiation signature genes derived in vitro ( n = 1763) with corresponding changes in a subset of the LG and HG cell lines grown as xenografts revealed a highly significant correlation ( r = 0.92, P < 0.001, Fig. 8A ) confirming differentiation-related transcriptional differences observed in vitro are largely retained when the cell lines are grown in vivo.

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